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KMID : 0545120220320091073
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Journal of Microbiology and Biotechnology
2022 Volume.32 No. 9 p.1073 ~ p.1085
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Distinct Molecular Mechanisms Characterizing Pathogenesis of SARS-CoV-2
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Lee Su-Jin
Kim Yu-Jin
Ahn Dae-Gyun
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Abstract
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has continued for over 2 years, following the outbreak of coronavirus-19 (COVID-19) in 2019. It has resulted in enormous casualties and severe economic crises. The rapid development of vaccines and therapeutics against SARS-CoV-2 has helped slow the spread. In the meantime, various mutations in the SARS-CoV-2 have emerged to evade current vaccines and therapeutics. A better understanding of SARS-CoV-2 pathogenesis is a prerequisite for developing efficient, advanced vaccines and therapeutics. Since the outbreak of COVID-19, a tremendous amount of research has been conducted to unveil SARSCoV-2 pathogenesis, from clinical observations to biochemical analysis at the molecular level upon viral infection. In this review, we discuss the molecular mechanisms of SARS-CoV-2 propagation and pathogenesis, with an update on recent advances.
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KEYWORD
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COVID-19, coronavirus, SARS-CoV-2, mechanism, pathogenesis
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